Our approach to chemical, biological, radiological, nuclear, and explosives (CBRNE) technical training brings together expertise in the science of CBRNE threats, non-traditional means of acquiring and producing CBRNE materials, and the sampling/analysis of these materials. Training with current threat information and realistic scenarios adds value to organizations responding to global events. Adequately trained individuals can cross barriers to understanding terminology and threat assessments with a well-rounded background in the science behind CBRNE threats.