About Signature Science
We serve government and commercial clients through a wide array of technical offerings that combine scientific rigor with proven quality assurance. Our expertise enhances the credibility and defensibility of government programs that provide for National Security, Public Safety and Security, and Health Security.

We Solve Problems Using Applied Science and Technology
Across many disciplines, our project teams are addressing some of the toughest challenges facing our local communities, our nation, and our world.
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A Compelling Work Environment and Culture
Signature Science employees benefit from a compelling work environment and corporate culture that are shaped by our pursuit of scientific innovation and service to our clients’ vital missions.

Tackling the Toughest Scientific Problems
We bring together the brightest minds from across the scientific disciplines to apply high-quality analysis and technical skills to meet new and developing challenges. Check our current openings to see where you fit.
News
Here’s what’s happening at Signature Science lately.
Our Interns’ Summer with SigSci Forensics
Each summer, Signature Science, LLC welcomes at least one intern to assist with research in our Center for Advanced Genomics (CAG). The research and validations performed at the CAG are shared with the forensic community in the form of open-source … MORE
Abstract: Nucleic acid synthesis is a dual-use technology that can benefit fields such as biology, medicine, and information storage. However, synthetic nucleic acids could also potentially be used negligently and ultimately cause harm, or be used with malicious intent to cause … MORE
The Case for Limiting “Sequences of Concern” to Those with Demonstrated Pathogenic Function
Abstract: Screening synthetic nucleic acid orders for sequences of concern is a necessary part of a healthy biosecurity regime, but it exacts costs for nucleic acid providers. Taxonomy is and will remain a critical part of the decision-making process for screening, … MORE